This project seeks to develop and implement various techniques of in vivo dose verification in proton therapy treatments and transfer those results to clinical practice, improving the clinical protocols to implement a precise proton therapy based on range verification. The key to be able to transfer this type of results to the clinic, as has been shown on other occasions [1] [2] [3],  is to obtain a sub-millimeter (or close to the millimeter) resolution in the determination of the position of the Bragg peak. To be able to recognize anatomical variations or errors of dose deposition in the order of 1 mm with respect to the treatment plan, it is necessary that both the detection of tissue activation (by PET or prompt gammas) and the calculation of the expected radioactive emission distribution from the treatment planning have sub-millimeter accuracy.